
Jennifer Morrison appeared in the finale in a cameo appearance as Allison Cameron. Amber Tamblyn also appeared briefly as Martha M.

Kal Penn was reported to be in talks and returned as Dr. Lisa Edelstein did not return for the series finale. It was announced that David Shore would direct and co-write the final episode of the show and also that Olivia Wilde would return as Thirteen for the penultimate episode and the series finale.

On February 8, 2012, in a joint statement issued by Fox and executive producers David Shore, Katie Jacobs, and Hugh Laurie, it was revealed that the season would be the last for House. Hugh Laurie's contract on House expired once the eighth season was over, and Laurie confirmed that once House was over, he would be moving on to strictly film roles. On January 8, 2012, Kevin Reilly (Fox President of Entertainment) stated that Fox had been "avoiding" a decision on the fate of the series, as it was "hard to imagine the network without House" and that the decision on the future of the series would be a "close call". Remy "Thirteen" Hadley) also left the show after the third episode in order to further her film career, although she returned at the end of the series. It was the only season not to feature Lisa Edelstein as Dr. I hope that Fox Network can find roles for this still youngish actor in which he can really shine.The eighth and final season of House was ordered on May 10, 2011. Even his throwaway lines are clearly understood. Yet he still is able to use to good effect his best features: open, Nordic face, expressive eyes and a delivery that is articulate but in no way stagey or affected. He also is that rarity: a patient who is the equal of House in intellect and wit-so much so that House takes to hanging out in Father Bresson's room in the ICU, not to treat or diagnose but for theological discussions! Regrettably, Jimmi Simpson has too little screen time in this episode, and through most of that he naturally enough is flat on his back. Yet he is so cool and self-contained, with an appealing iconoclasm, you have to like him if you have any youth in you. Victim of a false but damaging accusation of inappropriate contact with a young male parishioner, he has been bounced from one parish to another ever since. He remains a priest, he explains, because "it's my only marketable skill". Father Bresson has not been treated kindly by the Church and has lost his faith. Thirty-something actor Jimmi Simpson, best known for sporadic appearances as "Lyle, the Intern" on the Letterman show, does a super-cool yet sympathetic portrayal of a Catholic priest who comes to Princeton-Plainsboro after hallucinating the bleeding Christ at the door of his parish house in a ghetto neighborhood in New Jersey.
